{"id":22613,"date":"2021-01-05T12:14:04","date_gmt":"2021-01-05T09:14:04","guid":{"rendered":"https:\/\/bgenz.com\/Bio\/product\/pnaclamp-braf-kit-50-test-kit\/"},"modified":"2021-01-05T13:49:59","modified_gmt":"2021-01-05T10:49:59","slug":"pnaclamp-braf-kit-50-test-kit","status":"publish","type":"product","link":"https:\/\/bgenz.com\/Bio\/product\/pnaclamp-braf-kit-50-test-kit\/","title":{"rendered":"PNAClamp\u2122 BRAF Kit 50 test\/kit"},"content":{"rendered":"\n\n\n\n\n\n\n\n\n\n\n\n
No.<\/td>\n<\/td>\nReagent<\/td>\n<\/td>\nExon<\/td>\n<\/td>\nAmino Acid Change<\/td>\n<\/td>\nNucleotide Change<\/td>\n<\/td>\nCosmic No.<\/td>\n<\/tr>\n
1<\/td>\n<\/td>\nBRAF PNA mix #2<\/p>\n<\/td>\n<\/td>\n15<\/p>\n<\/td>\n<\/td>\np.V600E<\/td>\n<\/td>\nc.1799T>A<\/td>\n<\/td>\n476<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/td>\np.V600D<\/td>\n<\/td>\nc.1799_1800 TG>AT<\/td>\n<\/td>\n477<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/td>\np.V600K<\/td>\n<\/td>\nc.1798_1799 GT>AA<\/td>\n<\/td>\n473<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/td>\np.V600R<\/td>\n<\/td>\nc.1798_1799 GT>AG<\/td>\n<\/td>\n474<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/td>\np.V600A<\/td>\n<\/td>\nc.1799T>C<\/td>\n<\/td>\n18443<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n


<\/p>\n


<\/p>\n


<\/p>\n\n\n\n\n\n\n\n
\n
    \n
  • Ready-to-use kit with result available within 3hours.<\/b><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
\n
    \n
  • Compatible Real Time PCR
    \u00a0\u00a0\u00a0– ABI 7500, ABI 7900, ABI Step one plus, Bio-Rad CFX96, Light Cycler480 (Roche), Rotor-Gene Q.<\/b><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
\n
    \n
  • \u00a0Compatible Sample<\/b><\/li>\n<\/ul>\n

    \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 – Fresh tissue, FFPE tissue.<\/b><\/p>\n<\/td>\n<\/tr>\n

\n
    \n
  • Test Several Biomarkers in One Plate with same PCR conditions<\/b><\/li>\n<\/ul>\n

    \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 – eg. EGFR+KRAS or EGFR+BRAF+PIK3CA in one plate<\/b><\/p>\n<\/td>\n<\/tr>\n

\n
    \n
  • \u00a0High Sensitivity, Specificity with small amount of DNA<\/b><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

    BRAF mutation is found in several cancers including thyroid cancer, malignant melanoma, ovarian cancer, colorectal cancer. In case of thyroid cancer, there are over 40 different types of BRAF mutation. Of these mutations, the V600E mutation on exon 15, i.e. change of nucleotide from T to A in 1799th base that results in change from valine to glutamate in amino acids, is most important with over 90% of frequency. Especially, BRAF V600E mutation is detected with ca. 45% of frequency in papillary thyroid carcinoma and is considered a prognostic maker for thyroid cancer.<\/p>\n","protected":false},"featured_media":22608,"comment_status":"open","ping_status":"closed","template":"","meta":{"spay_email":""},"_links":{"self":[{"href":"https:\/\/bgenz.com\/Bio\/wp-json\/wp\/v2\/product\/22613"}],"collection":[{"href":"https:\/\/bgenz.com\/Bio\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/bgenz.com\/Bio\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/bgenz.com\/Bio\/wp-json\/wp\/v2\/comments?post=22613"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bgenz.com\/Bio\/wp-json\/wp\/v2\/media\/22608"}],"wp:attachment":[{"href":"https:\/\/bgenz.com\/Bio\/wp-json\/wp\/v2\/media?parent=22613"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}