{"id":22618,"date":"2021-01-05T12:14:06","date_gmt":"2021-01-05T09:14:06","guid":{"rendered":"https:\/\/bgenz.com\/Bio\/product\/pnaclamp-bcr-abl-kit-25-test-kit\/"},"modified":"2021-01-05T13:14:49","modified_gmt":"2021-01-05T10:14:49","slug":"pnaclamp-bcr-abl-kit-25-test-kit","status":"publish","type":"product","link":"https:\/\/bgenz.com\/Bio\/product\/pnaclamp-bcr-abl-kit-25-test-kit\/","title":{"rendered":"PNAClamp\u2122 BCR-ABL Kit 25 test\/kit"},"content":{"rendered":"
\n

BCR-ABL T315I\u00a0can be detected by PNAClamp\u2122 BCR-ABL Mutation Detection Kit.<\/span><\/span><\/p>\n

\u00a0<\/span><\/p>\n

\u00a0<\/span><\/p>\n

<\/span><\/p>\n\n\n\n\n\n
\n

\u00a0Mutations<\/b><\/span><\/p>\n<\/td>\n

\n

Size\u00a0<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u00a0Exon 6<\/span><\/p>\n<\/td>\n

\n

25 tests\u00a0<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

T315I (944C<\/t)\u00a0<><\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n


<\/div>\n
<\/div>\n<\/div>\n
\n

FEATURES<\/p>\n

\n
    \n
  • 01<\/span>High sensitivity and specificity even with small amount of DNA(1% LOD with 10 ng wild\/mutant type mixed DNA)<\/span><\/li>\n
  • 02<\/span>Real-Time PCR based ready-to-use kit<\/span><\/li>\n
  • 03<\/span>Short running time (within 3 hours)<\/span><\/li>\n<\/ul>\n<\/div>\n<\/div>\n

    PROCEDURE<\/h4>\n
      \n
    1. Sample preparation<\/span><\/li>\n
    2. Extraction of DNA<\/span><\/li>\n
    3. Real-time PCR<\/span><\/li>\n
    4. Result Analysis<\/span><\/li>\n<\/ol>\n

      COMPATIBLE REAL-TIME PCR MACHINE<\/h4>\n

      CFX96<\/span>
      (Bio-Rad)<\/span><\/p>\n

      ABI7500<\/span>
      (Thermo Fisher Scientific)<\/span><\/p>\n

      StepOnePlus<\/span>
      (Thermo Fisher Scientific)<\/span><\/p>\n

      Rotor-Gene Q<\/span>
      (Qiagen)<\/span><\/p>\n

      LightCycler 480II<\/span>
      (Roche)<\/span><\/p>\n

      ABI7900HT<\/span>
      (Thermo Fisher Scientific)<\/span><\/p>\n

      QuantStudio 5<\/span>
      (Thermo Fisher Scientific)<\/span><\/p>\n

      <\/p>\n","protected":false},"excerpt":{"rendered":"

      CML (Chronic myelogenous leukemia) patients who has consistently treated with Imatinib (Gleevec), have acquired point mutations in tyrosine kinase domain of BCR-ABL fusion gene. Especially, T315I mutation is known as a mutation associated with Imatinibresistance and observed with high frequency.
      It is important to monitor patients treated with Imatinibby BCR-ABLfusion gene mutation test to prevent therapy failure due to drug resistance by mutation.<\/p>\n","protected":false},"featured_media":22608,"comment_status":"open","ping_status":"closed","template":"","meta":{"spay_email":""},"_links":{"self":[{"href":"https:\/\/bgenz.com\/Bio\/wp-json\/wp\/v2\/product\/22618"}],"collection":[{"href":"https:\/\/bgenz.com\/Bio\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/bgenz.com\/Bio\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/bgenz.com\/Bio\/wp-json\/wp\/v2\/comments?post=22618"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bgenz.com\/Bio\/wp-json\/wp\/v2\/media\/22608"}],"wp:attachment":[{"href":"https:\/\/bgenz.com\/Bio\/wp-json\/wp\/v2\/media?parent=22618"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}