A single nucleotide polymorphism (SNP pronounced “snip”) is a DNA polymorphisms at the level of a single nucleotide, a single base mutation in DNA. SNPs are \u2018conserved\u2019 across the genome and represent the most simple form and most common source of genetic polymorphism in the human genome: 90% of all human DNA polymorphisms are associated with SNPs and variation frequency is about 1 every 1000bp in the human genome (Sachidanandam et al.,2001).<\/p>\n
The SNPs in the genome can affect gene functions, protein structure or expression and for these reasons they are used as markers in genetic disease studies (Kim & Mishra, 2007).<\/p>\n
It\u2019s sometimes possible to correlate a SNP with a particular trait or disease: susceptibility to disease may also be described as an \u2018unfortunate trait\u2019 that can be assessed checking if the mutated (unfortunate) polymorphism is carried in both alleles.<\/p>\n
SNPs testing can be applied to:<\/p>\n
Diagnostics \/ risk profiling
\nDrug response prediction
\nGene function identification<\/p>\n
Several SNPs have been associated to genetic susceptibility to different diseases and disorders like for example:
\n\u00b7 Hypertension
\n\u00b7 Fibrinolysis
\n\u00b7 Myocardial infarction
\n\u00b7 Ischemic stroke
\n\u00b7 Cancer
\n\u00b7 Metabolic disorders<\/p>\n","protected":false},"excerpt":{"rendered":"
RT-PCR test for detection of FTO gene mutation (rs9939609)<\/p>\n","protected":false},"featured_media":7830,"comment_status":"open","ping_status":"closed","template":"","meta":{"spay_email":""},"_links":{"self":[{"href":"https:\/\/bgenz.com\/Bio\/wp-json\/wp\/v2\/product\/8162"}],"collection":[{"href":"https:\/\/bgenz.com\/Bio\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/bgenz.com\/Bio\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/bgenz.com\/Bio\/wp-json\/wp\/v2\/comments?post=8162"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bgenz.com\/Bio\/wp-json\/wp\/v2\/media\/7830"}],"wp:attachment":[{"href":"https:\/\/bgenz.com\/Bio\/wp-json\/wp\/v2\/media?parent=8162"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}