PNAClamp™ IDH2 Kit 25 test/kit

Panagene
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Available on backorder

Expiry Date

N/A

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IDH2 is frequently mutated in glioma, acute myeloid leukemia, and myelodysplastic syndromes. Mutations generally involve point mutations at the R140 and R172 residues of the protein. Mutations in IDH1 and IDH2 result in deleterious “gain of function”: instead of converting isocitrate to α-ketoglutarate, mutated IDH1 or IDH2 converts isocitrate to 2-hydroxyglutarate. 2-hydroxyglutarate inhibits other proteins involved in epigenetic regulation.

EGP 49,875.00

Available on backorder

Total 11 IDH2 mutations can be detected.

 Murations

Size 

 Codon 140

Codon 172 

25 tests 

 4

7 

FEATURES

01High sensitivity and specificity even with small amount of DNA (1% LOD with 10 ng wild/mutant type mixed DNA)

  • 02Real-Time PCR based ready-to-use kit
  • 03Short running time (within 3 hours)

PROCEDURE

  1. Sample preparation
  2. Extraction of DNA
  3. Real-time PCR
  4. Result Analysis

COMPATIBLE SAMPE TYPE

– FFPE tissue
– Biopsy tissue
COMPATIBLE REAL-TIME PCR MACHINE
  1. CFX96(Bio-Rad)
  2. ABI7500 (Thermo Fisher Scientific)
  3. StepOnePlus (Thermo Fisher Scientific)
  4. Rotor-Gene Q (Qiagen)
  5. LightCycler 480II (Roche)
  6. ABI7900HT (Thermo Fisher Scientific)
  7. QuantStudio 5 (Thermo Fisher Scientific)
SKU: PNAC-5101 Category: Tags: , ,

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